Sitting more than 8 hours in a day doubles the risk of type 2 diabetes. It also increases the risk to common chronic diseases like heart problems or cancer by approx 10-20%. . As per researchers standing burned 0.15 kcal per minute more than sitting. So it can be concluded that replacing standing for sitting could be yet another behaviour change to help reduce the risk of long term weight gain. . For every 1 hour that you sit, try standing for 15 minutes. Also it is important to remember that these changes should be accompanied with healthy diet + exercise for significant weight changes